常见的 marker 基因以及一些文章的单细胞代码
人类细胞 marker
| Cell type | Cell-type specific markers | | :--------------- | :----------------------------------------------------------- | | Astrocyte | AGXT2L1, GFAP, ALDOC, SLC1A3, AGT, ALDH1L1 | | B cell | CD19, MS4A1, BANK1, BLK, IRF8, ABCB4, ABCB9, AFF4, AIDA, AIM2 | | Endothelial cell | VWF, PECAM1, CDH5, VEGFA, FLT1, ECSCR, ACYP1, ADGRL2, SELE, ICAM1 | | Epithelial cell | CDH1, MYLK, ANKRD30A, ABCA13, ABCB10, ADGB, SFTPB, SFTPC | | Erythrocyte | ALAS2, CA1, HBB, HBE1, HBA1, HBG1, GYPA | | Fibroblast | COL1A1, COL3A1, THY1, NECTIN1, FAP, PTPN13, C5AR2, LRP1 | | GMP | CD38, KIT, ADK, CD123, ALDH4A1, ANXA1, AP3S1, APLP2, APPL1, AREG, ASPM, CDKN3, CLSPN, DEPDC7, MCM10, MUCB2, SDC4, RMI2 | | HSC | CD34, ITGA5, PROM1, CD105, VCAM1, CD164, THY1, KIT, ACE, CMAH, ABCG2, CD41, ALDH1A1, BMI1 | | Macro/Mono/DC | CD68, CD14, MRC1, BHLHE40, CD93, CREM, CSF1R, CCL18, ICAM4, ACPP, ACSL3, ADGRE2, ADGRE3, CD209, CD83, CD1A | | Malignant cell | EPCAM, FOLH1, KLK3, KRT8, KRT18, KRT19 | | Mast cell | SLC18A2, ADIRF, ASIC4, BACE2, ENPP3, CADPS, CAPN3, CDK15, CMA1, GCSAML, MAML1, MAOB, CAVIN2 | | Myeloid cell | PTPRC, CD14, AIF1, TYROBP, CD163 | | Neuron | STMN2, RBFOX3, MAP2, TUBB3, CSF3, DLG4, ENO2 | | Neutrophil | ADGRG3, CXCL8, FCGR3B, MNDA, USP10, CSF3R, ANXA3, AQP9, BTNL8, LGALS13, G0S2, NFE4, IL5RA | | NK cell | FCGR3A, KLRB1, KLRD1, NKG7, XCL1, XCL2, NCR3, NCR1, CD247, GZMB, KLRC1, KLRK1 | | Oligodendrocyte | MOG, OLIG1, OLIG2, PDGFRA, PLP1, MBP, MAG, SOX10 | | Plasma cell | MZB1, BRSK1, AC026202.3, JSRP1, LINC00582, PARM1, TAS1R3 | | Progenitor | CD38, CASR, ALDH, CAR, KDR, MME, FLT3, CD90, CD123 | | T cell | CD3D, CD3G, CD3E |
小鼠细胞 marker
- **B细胞（B cell）**
- 标记基因: Blnk, Cd79a, Cd79b
- **浆细胞（Plasma）**
- 标记基因: Jchain
- **T细胞（T cell）**
- 标记基因: Cd3d, Cd3e, Cd3g
- **巨噬细胞（Macrophage）**
- 标记基因: Itgax
- **树突状细胞 (DC)**
- 标记基因: Fcgr2b, Cd209a, Itgam
- **腔内AV细胞 (Luminal AV)**
- 标记基因: Mfge8, Trf, Csn3, Wfdc18, Elf5, Ltf
- **腔内HS细胞 (Luminal HS)**
- 标记基因: Prlr, Cited1, Pgr, Prom1, Esr1
- **肌上皮细胞 (Myoepithelial)**
- 标记基因: Krt17, Krt14, Krt5, Acta2, Myl9, Mylk, Myh11
- **成纤维细胞 (Fibroblast)**
- 标记基因: Col1a1, Col1a2, Col3a1, Fn1
- **血管细胞 (Vascular)**
- 标记基因: Pecam1, Cdh5, Eng, Pdgfra, Pdgfrb, Fap
- **周细胞 (Pericyte)**
- 标记基因: Rgs5, Des, Notch3
文章及代码
Comprehensive single-cell aging atlas of healthy mammary tissues reveals shared epigenomic and transcriptomic signatures of aging and cancer
https://github.com/UcarLab/Mammary_gland_aging
Molecular and genetic insights into human ovarian aging from single-nuclei multi-omics analyses
https://github.com/ChenJin2020/Molecular-and-genetic-insights-into-human-ovarian-aging-from-single-nuclei-multi-omics-analyses
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